• GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample 

      Moe, Jenny Skumsnes; Bolstad, Ingeborg; Mørland, Jørg Gustav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)
      Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ...
    • History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Toft, Helge Prytz; Lien, Lars; Bolstad, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)
      Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ...
    • Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco 

      Bolstad, Ingeborg; Lien, Lars; Moe, Jenny Skumsnes; Pandey, Susmita; Toft, Helge; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background - Smoking and alcohol use often co-occur, and the use of nicotine-containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects ...
    • Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Walby, Fredrik A; Myhre, Martin Øverlien; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ...
    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...
    • The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol 

      Bramness, Jørgen Gustav; Skulberg, Knut Ragnvald; Skulberg, Andreas; Moe, Jenny Skumsnes; Mørland, Jørg Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-28)
      Aims - A high number of alcohol units required to feel a subjective effect of alcohol predicts future alcohol use disorders (AUDs). The subjective response to alcohol can be measured using the validated retrospective self-rated effects of alcohol (SRE) questionnaire. Few studies have investigated the specific relationship between SRE and blood alcohol concentration (BAC) in an experimental ...